TABLE 2.
Characterization of M. abscessus epetraborole-resistant mutants
| Strain | Batch | MIC (μM)a |
LeuS mutation | Other bacteria with LeuS mutation (reference)b | |
|---|---|---|---|---|---|
| CLR | EPB | ||||
| M. abscessus ATCC 19977 | 1.3 | 0.48 | None | ||
| RM1 | 1 | 1.5 | >100 | LeuS G393V | None |
| RM2 | 1 | 2.7 | >100 | LeuS T322I | E. coli, Proteus mirabilis (18) |
| RM3 | 1 | 1.3 | >100 | LeuS T323P | None |
| RM4 | 2 | 1.5 | >100 | LeuS S303L | M. tuberculosis (11) |
| RM5 | 2 | 1.8 | >100 | LeuS S303L | M. tuberculosis (11) |
| RM6 | 2 | 1.6 | >100 | LeuS S303L | M. tuberculosis (11) |
| RM7 | 2 | 1.4 | >100 | LeuS Y421D | M. tuberculosis (Y421C) (11) |
| RM8 | 2 | 0.9 | >100 | LeuS T322I | E. coli, P. mirabilis (18) |
| RM9 | 2 | 2.2 | >100 | LeuS F321V | None |
a
MIC values are the means from two independent experiments. CLR, clarithromycin; EPB, epetraborole.
b
Corresponding benzoxaborole resistance-conferring LeuS mutations reported for other bacteria.