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Mean V-7404 plasma concentration-time profiles for multiple ascending doses administered twice daily (BID), day 1 and day 14. Error bars indicate SD. Mean values BLQ were treated as zero for plotting purposes. The x axis is truncated at the time of the last quantifiable mean. Three participants were withdrawn before day 14 dosing, so n = 5 for the day 14 pharmacokinetic profile. BID, twice daily; BLQ, below the lower limit of quantification (LLOQ; 1.00 ng/ml); C, cohort.
