TABLE 1.

Demographics and baseline characteristics for single ascending dose safety population

Variable or category	Statistica	No. (%) of patients
		On placebo (n = 12)	On V-7404 at:						All participants (n = 36)
			200 mg (fasted, n = 4)	500 mg (fasted, n = 4)	500 mg (fed, n = 4)	1,000 mg (fasted, n = 4)	1,500 mg (fasted, n = 4)	2,000 mg (fasted, n = 4)
Gender
Male	n (%)	6 (50.0)	1 (25.0)	1 (25.0)	2 (50.0)	2 (50.0)	0 (0.0)	2 (50.0)	14 (38.9)
Female	n (%)	6 (50.0)	3 (75.0)	3 (75.0)	2 (50.0)	2 (50.0)	4 (100.0)	2 (50.0)	22 (61.1)
Race
American Indian or Alaska Native	n (%)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Asian	n (%)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Black or African American	n (%)	5 (41.7)	1 (25.0)	3 (75.0)	0 (0.0)	1 (25.0)	3 (75.0)	2 (50.0)	15 (41.7)
Native Hawaiian or other Pacific Islanders	n (%)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
White	n (%)	7 (58.3)	2 (50.0)	1 (25.0)	4 (100.0)	3 (75.0)	1 (25.0)	2 (50.0)	20 (55.6)
Multiple	n (%)	0 (0.0)	1 (25.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	1 (2.8)
Other	n (%)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)	0 (0.0)
Ethnicity
Hispanic or Latino	n (%)	1 (8.3)	1 (25.0)	0 (0.0)	1 (25.0)	0 (0.0)	0 (0.0)	0 (0.0)	3 (8.3)
Not Hispanic or Latino	n (%)	11 (91.7)	3 (75.0)	4 (100.0)	3 (75.0)	4 (100.0)	4 (100.0)	4 (100.0)	33 (91.7)
Age (yrs)	n	12	4	4	4	4	4	4	36
	Mean	31.3	35.3	31.3	23.3	30.0	26.8	32.0	30.3
	SD	7.3	5.6	3.4	4.3	5.5	3.8	10.1	6.7
	CV%	23.4	15.8	10.9	18.7	18.3	14.1	31.7	22.2
	Minimum	21	30	27	19	23	23	23	19
	Median	31	34	32	23	31	26	30	30
	Maximum	45	43	34	29	36	32	45	45
Ht (cm)	n	12	4	4	4	4	4	4	36
	Mean	168.71	167.00	170.63	171.63	164.25	162.43	167.75	167.76
	SD	7.89	6.23	2.36	13.59	4.99	4.19	13.23	8.09
	CV%	4.7	3.7	1.4	7.9	3.0	2.6	7.9	4.8
	Minimum	154.0	160.5	168.5	156.5	159.0	158.0	149.0	149.0
	Median	167.5	167.0	170.0	172.5	164.5	162.1	172.0	168.0
	Maximum	180.0	173.5	174.0	185.0	169.0	167.5	178.0	185.0
Wt (kg)	n	12	4	4	4	4	4	4	36
	Mean	73.70	82.93	67.55	65.93	71.80	67.15	76.45	72.54
	SD	13.97	13.95	10.45	9.30	13.36	14.71	15.88	13.27
	CV%	19.0	16.8	15.5	14.1	18.6	21.9	20.8	18.3
	Minimum	56.8	66.0	54.3	53.6	55.9	52.5	58.4	52.5
	Median	71.1	84.7	69.8	67.0	72.7	66.1	78.2	71.1
	Maximum	97.2	96.3	76.4	76.2	85.9	83.9	91.1	97.2
Body mass index (kg/m2)	n	12	4	4	4	4	4	4	36
	Mean	25.88	29.55	24.18	22.58	26.60	25.00	26.70	25.80
	SD	3.86	2.91	4.54	2.41	4.52	4.65	2.54	3.89
	CV%	14.9	9.9	18.8	10.7	17.0	18.6	9.5	15.1
	Minimum	20.0	25.7	19.3	19.8	22.3	20.1	23.7	19.3
	Median	25.4	30.3	23.8	22.5	26.8	24.6	26.8	25.7
	Maximum	31.7	32.0	29.9	25.6	30.5	30.7	29.5	32.0

^aCV%, coefficient of variation.