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. 2021 Sep 13;13:471–503. doi: 10.2147/BCTT.S316667

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© 2021 Yap et al.

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Fabrication of smart nanofiber matrices for breast cancer therapy. Polyphenolic compounds (PLP) from M. indica have been studied extensively as anti-inflammatory and anti-cancer agents. In the proposed future study, M. indica PLP will be cross-linked to silk fibroin (cocoon) nanofibers before being conjugated with PNIPAAm-PEG-Tat to yield PNIPAAm-PLP-Tat, which can then be released in a thermal responsive burst at breast tumor tissues. The use of cell-penetrating peptide (Tat) permits targeted intracellular transport of PLP into breast cancer cells.