Table 4.
Number of differentially methylated positions (DMPs) (p < 0.01 and |Δβ| ≥ 0.06) in the six pairs of subgroups of CSU patients.
| Subgroup (No.) | DMP | Δβ | p value | Chr. | DMG | Related diseases# |
|---|---|---|---|---|---|---|
| High tIgE (64) vs. normal tIgE (31) | cg05001007 | −0.137 | 1.56E−03 | 10 | ||
| cg08506353 | −0.120 | 2.35E−03 | 6 | HLA-DPB2 | AIDs (ATDs, systemic sclerosis, SLE, Wegener’s granulomatosis, IgA nephropathy), neoplasms (uterine cervix) | |
| cg14782559 | 0.177 | 5.23E−03 | 6 | COL11A2 | AIDs (primary Sjogren’s syndrome, RA, Wegener’s granulomatosis), osteoarthritis, vasculitis | |
| cg15019001 | −0.122 | 7.05E−03 | 6 | HLA-DPB2 | AIDs (ATDs, systemic sclerosis, SLE, Wegener’s granulomatosis, IgA nephropathy), neoplasms (uterine cervix) | |
| cg07440017 | 0.091 | 7.32E−03 | 3 | |||
| Anti-TPO + (18) vs. anti-TPO − (77) | cg24443559 | −0.134 | 1.90E−03 | 7 | WDR60 | Short rib-polydactyly syndrome, osteochondrodysplasias |
| Anti-TG + (24) vs. anti-TG − (71) | cg12873598 | −0.071 | 3.68E−03 | X | ||
| cg02448295 | 0.153 | 1.65E−03 | 6 | BRD2 | Melanoma, breast neoplasms, osteosarcoma, leukemia, epilepsy | |
| cg11720573 | −0.132 | 3.67E−03 | 15 | ABHD2 | Chronic obstructive pulmonary disease, selective IgA deficiency, cancers, coronary artery disease | |
| AE + (35) vs. AE − (60) | cg26864304 | 0.127 | 7.16E−03 | 6 | ||
| cg11370814 | −0.072 | 9.84E−03 | 2 | |||
| UAS ≤ 4 (32) vs. UAS > 4 (63) | cg00917413 | −0.083 | 8.53E−03 | 7 | CAV2 | Neoplasms (breast, prostate, thyroid), carcinoma (lung, renal cell), glaucoma, type II diabetes, Alzheimer’s diseases |
| Recurrent (30) vs. non-recurrent (65)^ | cg01992742 | −0.114 | 6.13E−03 | 20 | NCOA3 | Neoplasms (breast, prostate, urinary bladder, ovarian, colorectum, lung, brain), carcinoma (hepatocellular, non-small-cell lung, adenocarcinoma) |
CSU, chronic spontaneous urticaria; TPO, thyroid peroxidase; TG, thyroglobulin; tIgE, total IgE (high tIgE, tIgE > 100 IU/ml, normal tIgE, tIgE ≤ 100 IU/ml); sIgE, specific IgE; AE, angioedema; DMP, differentially methylated position; Chr., chromosome; DMG, differentially methylated gene; AID, autoimmune disease; ATD, autoimmune thyroid disease; SLE, systemic lupus erythematosus; RA, rheumatoid arthritis.
#Annotation of related diseases was conducted in the Gene-Cloud of Biotechnology Information database.
^The average recurrence interval of the 30 recurrent CSU patients was 10.8 (range: 2–30) years.