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Current traces of reconstituted VDAC isoforms. (A–E) Current traces of reconstituted hVDACCF/ND isoforms described as in Fig. 3 were obtained by clamping membrane 15 s voltage steps of ±5 mV over voltage window of ±50 mV. (F) Conductance G/G0 of VDAC isoforms as a function of the applied voltage. The voltage dependence of most isoforms exhibits a bell shape; only hVDAC3CF/ND shows, in the absence of reducing agents, almost no voltage dependence.
