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. 2021 Sep 7;17(9):e1009761. doi: 10.1371/journal.pgen.1009761

Table 1. The CovR direct regulon in BM110.

First gene in Transcriptional Units (TUs) Number of genes in TUs ChIP-seq (FE) RNA-seq (mean Log2 FC) Genes included in TUs Main functions
LPxTG proteins
BQ8897_RS10700 1 6,3 7,6 hvgA hypervirulent adhesin
BQ8897_RS05875 1 7,0 4,2 fbsA Adhesin
BQ8897_RS02735 1 4,2 1,5 pbsP Adhesin
BQ8897_RS03985 2+6 6,3 3,0 pil-1 operon Adhesin and regulator (2 TU)
BQ8897_RS06775 1 5,5 1,7 scpB Serine protease (C5a peptidase)
BQ8897_RS02910 1 7,2 5,4 scpB2 Serine protease (frameshifted)
BQ8897_RS04140 4 6,6 1,5 scpB4A Serine protease + Secreted small protein (134 aa)
Secreted
BQ8897_RS04080 12 4,3 4,6 cyl operon ß-hemolysin/cytotoxin synthesis and export
BQ8897_RS04945 2 6,7 7,7 fbsB Adhesin
BQ8897_RS04215 1 4,4 3,7 nucA DNA/RNA non-specific endonuclease
BQ8897_RS02690 1 6,1 5,9 Predicted esterase/lipase
BQ8897_RS01270 1 4,2 7,5 Uncharacterized peptide (49 aa)
BQ8897_RS02625 1 6,3 5,0 Uncharacterized small protein (141 aa)
BQ8897_RS09870 1 6,4 6,5 Uncharacterized protein (586 aa—ATG miss-annotation in RefSeq)
Membrane and cytoplasmic
BQ8897_RS10135 2 5,3 2,1 rgfAC Two-component system
BQ8897_RS09785 1 6,4 2,9 pepO Cytoplasmic endopeptidase (M13 family)
BQ8897_RS08070 6 5,7 6,7 pppK Uncharacterized—polyphosphate kinase
BQ8897_RS04650 3 8,1 2,0 ABC transporter (Amino acid transport)
BQ8897_RS05655 1 7,1 3,1 Membrane protein (Abx1-like)
BQ8897_RS04625 1 7,2 2,6 (fbsC*) Membrane protein (co-regulation with the frameshifted FbsC adhesin)
BQ8897_RS03040 1 4,4 3,1 Methyltransferase (frameshifted)