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. 2021 Sep 3;12:720354. doi: 10.3389/fimmu.2021.720354

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Copyright © 2021 Gao, Hong, Zhao, Pan, Sun, Kong, Wang, Wang, Wang, Yan, Wang, Huang and Zhao

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Mucosa-associated invariant T (MAIT) cell functional changes in 16 gut acute graft-versus-host disease (aGVHD) patients before and after the onset of gut aGVHD. (A) The changes of MAIT cell number at three posttransplant time points, namely, at the time of neutrophil engraftment, at the onset of gut aGVHD, and at the CR of gut aGVHD. (B) The changes of transcription factors PLZF, T-bet, and Rorγt in patients with gut aGVHD at different points. (C) Posttransplant comparison of MAIT1 and MAIT17 subsets based on the expression of transcription factors T-bet and Rorγt respectively in gut aGVHD patients. (D) The changes of activation markers and chemokine receptors in patients with gut aGVHD at different points. (E) Cluster heat map of species abundance at the genus level. (F) LDA score distribution histogram and cladogram. Levels of significances are given as p-values with ***≤0.01 and **≤0.5.