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. 2021 Sep 3;12:720354. doi: 10.3389/fimmu.2021.720354

Table 1.

Univariate and multivariate analyses of risk factors for the occurrence of gut aGVHD.

Characteristics Univariate analyses Multivariate analyses
HR 95% CI p-value HR 95% CI p-value
Donor gender 0.400 0.114–1.405 0.153
Donor ages 1.018 0.984–1.054 0.296
Recipient ages 0.998 0.961–1.036 0.919
Recipient gender 2.563 0.931–7.053 0.068 2.850 1.001–8.108 0.050
ABO-matched grafts 3.520 1.223–10.133 0.020 2.992 1.022–8.762 0.046
disease status (pretransplant CR vs. NR) 0.043 0–61.587 0.395
Transplant types 0.733 0.209–2.571 0.627
Donor-recipient gender match 0.923 0.496–1.717 0.799
Conditioning regimen 0.973 0.480–1.972 0.939
G-BM CD34+ counts 2.446 0.579–10.335 0.224
G-BM Treg cell counts 8.126 0.066–999.075 0.393
G-BM Tc cell counts 1.088 0.981–1.206 0.111
G-BM MAIT cell counts 1.180 0.557–2.501 0.665
G-PB CD34+ counts 1.008 0.743–1.367 0.961
G-PB Treg cell counts 1.110 0.909–1.356 0.307
G-PB Tc cell counts 1.004 0.996–1.011 0.337
G-PB MAIT cell counts 0.906 0.801–1.025 0.116
Graft CD34+ counts 0.988 0.777–1.256 0.919
Graft Treg cell counts 1.114 0.913–1.358 0.288
Graft Tc cell counts 1.004 0.996–1.011 0.321
Graft CD4/CD8 1.226 0.688–2.186 0.489
Graft MNC 0.983 0.760–1.270 0.893
Graft MAIT cell counts ≥5.3 × 106/kg (median value) vs. <5.3 × 106/kg 0.174 0.039–0.772 0.021 0.137 0.030–0.620 0.010
Day +30 MAIT cell counts ≥1.1/μl (median value) vs. <1.1/μl 0.670 0.239–1.884 0.448
Day +60 MAIT cell counts ≥2.9/μl (median value) vs. <2.9/μl 0.387 0.121–1.235 0.109

The factors with p < 0.1 in univariate analysis were included in multivariate analysis.

P < 0.05 was marked in bold.

G-BM, Graft bone marrow; G-PB, Graft peripheral blood.