TABLE 2.
Detection of Organisms in Case-only Specimens, by Specimen and Test
| Organism | Test | All Cases | CXR+ Cases |
|---|---|---|---|
| A. Blood | N = 615 | N = 279 | |
| Anya | Culture | 26 (4.2) | 14 (5.0) |
| Streptococcus pneumoniae | Culture | 10 (1.6) | 7 (2.5) |
| S. pneumoniae VT (PCV13) | Culture | 2 (0.3) | 2 (0.7) |
| S. pneumoniae non-VT (PCV13) | Culture | 8 (1.3) | 5 (1.8) |
| Haemophilus influenzae | Culture | 3 (0.5) | 2 (0.7) |
| H. influenzae type b | Culture | 1 (0.2) | 0 (0.0) |
| H. influenzae non-type b | Culture | 2 (0.3) | 2 (0.7) |
| Staphylococcus aureus | Culture | 3 (0.5) | 1 (0.4) |
| Salmonella spp.b | Culture | 2 (0.3) | 1 (0.4) |
| Other nonfermentative Gram-negative rodsc | Culture | 1 (0.2) | 0 (0.0) |
| Enterobacteriaceaed | Culture | 4 (0.7) | 1 (0.4) |
| Neisseria meningitides | Culture | 2 (0.3) | 1 (0.4) |
| Candida sp. | Culture | 1 (0.2) | 1 (0.4) |
| Mixede | Culture | 1 (0.2) | 0 (0.0) |
| Contaminants | Culture | 43 (7.0) | 24 (8.6) |
| B. Lung aspirate f | |||
| N = 22 | N = 21 | ||
| Any | Culture | 5 (22.7) | 5 (23.8) |
| PCR | 6 (35.3) | 6 (35.3) | |
| Culture or PCR | 8 (36.4) | 8 (38.1) | |
| S. pneumoniae | Culture | 5 (22.7) | 5 (23.8) |
| PCR | 5 (29.4) | 5 (29.4) | |
| Culture or PCR | 7 (31.8) | 7 (33.3) | |
| S. pneumoniae VT (PCV13)g | Culture or PCR | 4 (18.2) | 4 (19.2) |
| S. pneumoniae non-VT (PCV13)g | Culture or PCR | 2 (9.1) | 2 (9.5) |
| Moraxella Catarrhalis | Culture | 0 (0.0) | 0 (0.0) |
| PCR | 3 (17.6) | 3 (17.6) | |
| Culture or PCR | 3 (13.6) | 3 (14.3) | |
| H. influenzae h | Culture | 1 (4.5) | 1 (4.8) |
| PCR | 2 (11.8) | 2 (11.8) | |
| Culture or PCR | 2 (9.1) | 2 (9.5) | |
| C. Pleural fluid f,i | |||
| N = 1 | N = 1 | ||
| Any | Culture | 1 (100) | 1 (100) |
| S. aureus | Culture | 1 (100) | 1 (100) |
| D. Induced sputum | |||
| N = 575 | N = 255 | ||
| Mycobacterium tuberculosis | Culture | 7 (1.2) | 7 (2.7) |
aExcludes contaminants.
bNontyphoidal Salmonella species (N = 2).
cAcinetobacter species (N = 1).
dEnterobacter cloacae (N = 1); Escherichia coli (N = 3); Klebsiella pneumoniae (N = 1).
eE. coli and K. pneumoniae (N = 1).
fRestricted to specimens obtained within 3 days of admission and those pathogens determined by the clinical review team to be noncontaminants. Data reflect any positivity; some children were positive for multiple organisms on lung aspirate. 22/22 cases had lung aspirate culture results available, and 17/22 had lung aspirate PCR results available. Denominator for “Culture or PCR” rows reflects children with either culture or PCR (N = 22).
gTwo cases were positive for S. pneumoniae by lung aspirate PCR only so no lung aspirate serotype data available. For one of these cases, the serotype detected on induced sputum (ST = 1) was assumed to the ST that would have been detected on lung aspirate because it is rarely detected in healthy children. One case was positive for an S. pneumoniae non-PCV13 type serotype on both blood culture and lung aspirate culture.
hOne case was positive for H. influenzae by culture and PCR; serotyping results for culture isolate were missing but were H. influenzae non-type b by PCR. One case positive for H. influenzae type b by PCR.
iOne case with a pleural fluid specimen was missing pleural fluid PCR results.