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. 2021 Aug 20;129(7):720–734. doi: 10.1161/CIRCRESAHA.121.319517

Figure 6.

Figure 6.

Enhanced insulin sensitivity in mIGFREO (mutant IGF-1R EC overexpressing) mice.A–C, Data from low-dose hyperinsulinemic-euglycemic clamp studies on mIGFREO and WT (wild type) littermates showing blood glucose (A), glucose infusion rate (B), and rate of glucose disappearance (Rd; C) during hyperinsulinemic-euglycemic clamp (WT, n=8; mIGFREO, n=8). D–F, Tissue-specific glucose uptake into brown adipose tissue (D; WT, n=10; mIGFREO, n=9), gastrocnemius skeletal muscle (E; WT, n=7; mIGFREO, n=6), and vastus skeletal muscle (F; WT, n=8; mIGFREO, n=7). G and H, Insulin (intraperitoneal injection; 0.75 U/kg, 15 min) stimulated tyrosine phosphorylation of IR (insulin receptor; pY-IR) in liver (G; WT, n=8; mIGFREO, n=8) and skeletal muscle (H; WT, n=5; mIGFREO, n=6). Data expressed as mean±SEM. A and B, #P<0.05, total glucose flux WT vs mIGFREO mice. D–H, *P<0.05 WT vs mIGFREO. Data in A and B were analyzed using 2-way ANOVA, followed by Bonferroni multiple comparisons test. All other data were analyzed by unpaired Student t test.