Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Schematic role of STING signaling in autophagy and mitochondrial homeostasis. STING could be activated by all kinds of pathogenic microorganisms and mtDNA. The activated STING could induce the production of IFNs and cytokines through phosphorylation of IRF3. In addition, STING directly interacted with LC3 and further activated ATG5-dependent autophagy. Moreover, P62, which is a key receptor for regulating autophagy, could degrade STING.
