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Schematic roles of TLRs signaling in autophagy and mitochondrial homeostasis. According to the availability of adaptor molecules, activation of TLRs signaling induces MyD88-TRAF6 pathway and TRIF pathway. On one hand, TLRs downstream signaling molecules affect mitochondrial homeostasis via regulating ROS production. On another hand, these molecules are also involved in the formation of autolysosome through regulates activity of autophagy-related genes.
