Figure 1.

Serum ZIKV nAb titers over time in infants born to women with laboratory-confirmed infection during pregnancy. Titers were determined in consecutive serum samples by the virus neutralization test, and log₂ values are shown. Fitted lines represents the polynomial regression (lowess) of (A) all measures (n = 98); (B) cases stratified by the confirmation of Zika infection only by detection of ZIKV IgM (green, n = 14), ZIKV RNA in blood and/or urine (blue, n = 27), or both ZIKV IgM and ZIKV RNA (purple, n = 18), or without confirmation of infection (red, n = 39); and (C) cases stratified by the gestational age at infection, occurring in the first trimester (up to 13 weeks, red, n = 33), in the second trimester (from 14 to 26 weeks, green, n = 45), or during the third trimester (after 27 weeks, blue, n = 20). Abbreviations: nAb, neutralizing antibodies; ZIKV, Zika virus.