Table 4.
Detection of Zika Virus Neutralizing Antibodies According to Diagnosis of Zika Infection
| Laboratory Diagnosis of Zika Infectionc | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| No. Positived | ||||||||||
| ZIKV IgM Only | ZIKV IgM + ZIKV RNA | ZIKV RNA Only | No. Negative | No. Not Done | ||||||
| Age, moa | VNTb + | VNT − | VNT + | VNT − | VNT + | VNT − | VNT + | VNT − | VNT + | VNT − |
| 0–3 | 7 | … | 12 | 1 | 8 | 2 | 9 | 1 | … | 1 |
| 3–6 | 4 | 2 | 5 | … | 7 | 2 | 9 | 1 | … | 1 |
| 6–12 | … | … | … | … | 1 | 3 | 3 | 2 | 1 | 3 |
| > 12 | … | 1 | … | … | … | 4 | … | 4 | … | 4 |
| Total | 11 | 3 | 17 | 1 | 16 | 11 | 21 | 8 | 1 | 9 |
Abbreviations: IgM, immunoglobulin M; VNT, virus neutralization test; ZIKV, Zika virus.
aAge of infants at sample collection to carry out ZIKV VNT.
bVNT was considered positive in samples with ZIKV neutralizing antibodies titer >1:40.
cLaboratory diagnosis of Zika infection was performed by detection of ZIKV IgM and ZIKV RNA in blood and/or urine. Investigation was positive in 59 children, negative in 29, and not done in 10 infants.
dDistribution analysis of ZIKV VNT results was performed between infants with positive results for only ZIKV IgM, ZIKV IgM and ZIKV RNA, and only ZIKV RNA. χ 2 test, P = .027.