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. 2021 Sep 17;7(38):eabf2073. doi: 10.1126/sciadv.abf2073

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Copyright © 2021 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC).

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Fig. 2. — (A) Timeline for injections of Poly I:C. (B) Up-regulated genes are enriched for microglial markers and IFN response pathways, as shown by gene set enrichment analyses. Genes are ranked by differential expression log₂ fold change. NES, normalized enrichment statistic. (C) Analogous enrichment of microglia and IFN response pathways is observed among up-regulated genes in ASD from postmortem frontal and temporal cortex samples compared with matched controls.