Figure 2. Summary of analysis of carcinogen exposure of organoids following adjustment for cell composition.

(A) Boxplot to show the proportion of gene-wise variance explained by each covariate within the mixed-effects regression model. (B) Volcano plot of carcinogen DEGs. ‘Prior’ and ‘Novel’ denote genes that were and were not previously identified in original analysis respectively (C) Volcano plot of BarcUVa-Seq analysis. DEGs only identified in BarcUVa-Seq are denoted light blue, while genes that were also present nominally (dark blue) and following Bonferroni correction (red) in carcinogen analysis are also shown. N.S denotes genes that were not significant.