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. 2021 Sep 14;12(19):1920–1936. doi: 10.18632/oncotarget.28068

Figure 5. TUNEL analysis for apoptosis detection in tumor sections of xenografted Balb-c/nude mice.

Figure 5

(A) Representative images of TUNEL assay of tumor sections from the different experimental groups administered intraperitoneally (i.p.) with: Vehicle, 4bt (80 mg/Kg), 4bc (80 mg/Kg), paclitaxel (20 mg/Kg), Doxorubicin (10 mg/Kg) + Cyclophosphamide (100 mg/Kg) followed by paclitaxel (10 mg/Kg) (AC-T) and Doxorubicin (10 mg/Kg) + Cyclophosphamide (100 mg/Kg) followed by KIF11 inhibitor 4bt (AC-4bt). (B) Quantitative analyses of apoptotic cell area for each experimental group. Data represent mean ± SEM of three independent experiments. *** p < 0.001, **** p < 0.0001 as compared to control group (vehicle). Bars: 50 μm.