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. Author manuscript; available in PMC: 2022 Jan 23.
Published in final edited form as: Science. 2021 Jun 3;373(6553):eabf9277. doi: 10.1126/science.abf9277

Fig. 6. Ligand-receptor interactions between CXCL12+ fibroblasts and CXCR4+ early B cells in the dura.

Fig. 6.

(A) Dot plot presenting the expression level of featured genes in fibroblasts and B cells at different maturation stages. (B) NicheNet analysis displaying the putative interaction score between fibroblasts-derived ligands and B cell receptors. (C) Representative confocal images of freshly prepared dura explant from a Cxcl12-DsRed reporter mouse (Tomato-lectin-488 injected iv. before perfusion). (D) FACS analysis of dura fibroblasts from Cxcl12-DsRed reporter mice (representative of three mice; data generated from a single experiment). (E) FACS analysis of CXCR4 expression in early, late, and mature B cells from dura and BM. (F) frequency of CXCR4+ B cells in the three B cells subsets from dura and BM (mean ± SEM; n=4 mice; data generated from a single experiment).