Figure 4.

Effects of AhR agonist, SB203580, on cell viability and proliferation in Tax-treated gastric cancer cells. (A and B) AGS and NCI-N87 cells were treated with Tax or co-treated with Tax and SB203580, an agonist of AhR. Then, the protein expression levels of AhR and CYP1A1 were assessed using western blotting and quantified. (C and D) The cell viability was assessed using a Cell Counting Kit-8 assay. (E) Cell colony formation assays were performed. ^***P<0.001 vs. the control; ^#P<0.05, ^##P<0.01 and ^###P<0.001 vs. Tax. Tax, taxifolin; AhR, aryl hydrocarbon receptor; CYP1A1, cytochrome P450 1A1.