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. 2021 Sep 7;97(10):e975–e987. doi: 10.1212/WNL.0000000000012463

Figure 2. Weight Loss, Muscle Weakness, and Twitch and Tetanus Force Decreased in Patient Immunoglobulin (Ig)–Injected Mice.

Figure 2

(A) Scheme of passive experimental autoimmune myasthenia gravis. (B) Decreased body weight in patient Ig-injected mice, not in healthy Ig-injected mice, compared with phosphate-buffered saline (PBS)–injected control mice. (C) Declined forelimb grip strength in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (D) Increased forelimb grip fatigue in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (E) Reduced forelimbs hanging time in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (F) Decreased running time in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (G) Reduced single twitch force by muscle stimulation in patient Ig-injected mice, not in healthy IgG-injected mice, compared with PBS-injected control mice. (H) Reduced single twitch force by sciatic nerve stimulation in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (I) Representative tetanic curves at stimulation frequency 50 and 100 Hz by muscle stimulation. (J) Reduced tetanic force by muscle stimulation at different stimulation frequencies in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (K) Representative tetanic curves at stimulation frequency 50 and 100 Hz by sciatic nerve stimulation. (L) Reduced tetanic force muscle stimulation at different stimulation frequencies in patient Ig-injected mice, not healthy Ig-injected mice, compared with PBS-injected control mice. n = 3 mice per group, **p < 0.01.