Skip to main content
. 2021 Sep 7;97(10):e975–e987. doi: 10.1212/WNL.0000000000012463

Figure 4. Increased Neuromuscular Junction (NMJ) Fragment, Reduced Acetylcholine Receptor (AChR) Density, and Increased Denervation in the NMJ of Patient Immunoglobulin (Ig)–Injected Mice.

Figure 4

(A) z-Stack images of NMJs from phosphate-buffered saline (PBS)–injected control mice, healthy Ig-injected mice, and patient Ig-injected mice. Scale bars 10 μm. (B–E) Quantitative analysis of data. (B) Increased fragments of AChR clusters in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (C) Reduced AChR area per NMJ in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (D) Decreased AChR intensity in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. (E) Reduced overlap area of neurofilament-L/synapsin-1 and AChR staining in patient Ig-injected mice, not in healthy Ig-injected mice, compared with PBS-injected control mice. n = 3 mice per group. **p < 0.01.