Table 1.

Effect of ADSCs in PNI animal models.

Stem cell characteristics	Animal/nerve	Experimental model	Delivery system	Contribution to PNI regeneration	Reference
ADSCs	Mice sciatic nerve	5 mm nerve gap	Gelatin hydrogel tube	Promoted formation of myelin, restoration of denervation muscle atrophy	[95]
hADSCs	Rabbit peroneal	40 mm nerve gap	Vein conduit refilled with fibrin	Promoted myelination and axonal regeneration	[96]
ADSCs	Rat sciatic nerve	Nerve crush model	Perineural transplantation by cell injection	Gained better motor functional recovery and early proregeneration	[97]
ADSCs	Mouse sciatic nerve	Nerve crush model	Intravenous administration of ADSCs	Accelerated the functional recovery and reduced inflammatory infiltrates	[26]
ADSCs	Dog facial nerve	7 mm nerve gap	Core-Tex tube filled alginate hydrogel	Promoted nerve diameter, nerve number, and electrophysiological recovery	[39]
ADSCs	Rat sciatic nerve	10 mm nerve gap	Collagen conduit filled with fibrin-agarose hydrogels	Enhanced sensory and motor functional recovery	[98]
ADSCs	Rat sciatic nerve	10 mm nerve gap	Silicon rubber conduit	Augmented the functional recovery and axonal regeneration	[99]
ADSCs	Rat sciatic nerve	10 mm nerve gap	GGT (genipin-gelatin-tricalcium phosphate) nerve conduit	Promoted SFI and CMAPs (compound muscle action potentials)	[100]
ADSCs	Rat sciatic nerve	10 mm nerve gap	Acellular nerve tube	Increased walking behavior, nerve conduct velocity, myelinated fiber density	[101]
ADSCs	Rat sciatic nerve	10 mm nerve gap	Fibrin conduit	Enhanced axonal regeneration and angiogenesis	[36]
ADSCs	Rat sciatic nerve	10 mm nerve gap	3D-engineering of cellularized conduits	Augmented functional and histological assessment	[102]
ADSCs	Rabbit sciatic nerve	20 mm nerve gap	Acellular allogenic nerve	Improved recovery of nerve function, morphology, and tensile mechanical properties.	[103]
ADSCs	Rat sciatic nerve	Nerve transection	Fibrin glue	Enhanced the process of nerve regeneration and angiogenesis	[104]
ADSCs	Rat sciatic nerve	Nerve transection	Fibrin-hydrogel nerve conduits (FNC)	Promoted early nerve regeneration	[105]