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. 2021 Sep 10;2021:3651735. doi: 10.1155/2021/3651735

Table 1.

Effects of different estrogen and progesterone treatments on the adult hippocampal neurogenesis of mammals.

Treatment Model organism Neuron proliferation Neuron survival Reference
graphic file with name NP2021-3651735.tab1.i001.jpg SD rats ↑ [58]
graphic file with name NP2021-3651735.tab1.i002.jpg ↑
graphic file with name NP2021-3651735.tab1.i003.jpg SD rats ↔ [59]
graphic file with name NP2021-3651735.tab1.i004.jpg ↔
graphic file with name NP2021-3651735.tab1.i005.jpg SD rats ↓ [60]
graphic file with name NP2021-3651735.tab1.i006.jpg SD rats ↑ [61, 62]
graphic file with name NP2021-3651735.tab1.i007.jpg SD rats ↑ [61, 63]
graphic file with name NP2021-3651735.tab1.i008.jpg ↑
graphic file with name NP2021-3651735.tab1.i009.jpg SD rats ↑ ↓ [64]
graphic file with name NP2021-3651735.tab1.i010.jpg SD rats ↔ ↑ [65]
graphic file with name NP2021-3651735.tab1.i011.jpg ↔ ↓
graphic file with name NP2021-3651735.tab1.i012.jpg SD rats ↔ ↓ [66]
graphic file with name NP2021-3651735.tab1.i013.jpg ↔ ↔
graphic file with name NP2021-3651735.tab1.i014.jpg Wistar rats ↔ ↔ [67]
graphic file with name NP2021-3651735.tab1.i015.jpg ICR mice ↓ ↓ [31]
graphic file with name NP2021-3651735.tab1.i016.jpg ↔
graphic file with name NP2021-3651735.tab1.i017.jpg ↑ ↑
graphic file with name NP2021-3651735.tab1.i018.jpg ↑

Note: “OVX” indicates bilateral ovarian resection; the green bar indicates estrogen or estradiol benzoic acid; the red bar indicates estrone; the orange bar indicates progesterone; the purple bar indicates benzoic acid and progesterone. The up arrows indicate upregulation, the down arrows indicate downregulation, and the horizontal bars indicate no change. Abbreviations: E2: estradiol; BrdU: bromodeoxyuridine; EB: estradiol benzoate; FST: forced swimming test; P4: progesterone; SD rats: Sprague-Dawley rats.