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. 2021 Sep 10;2021:4190764. doi: 10.1155/2021/4190764

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Copyright © 2021 Wenying Zhang et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

PMC Copyright notice

RNA interference targeting HOTAIR generated downregulation of stem cell markers. (a, b) Cancer stem cells of HeLa enriched by treatment with cisplatin (a) or culture in a serum-free medium (b) showed elevated expression of HOTAIR. (c–h) RNA interference targeting HOTAIR downregulated the stem cell markers NANOG, OCT4, CD44, ALDH1, CD133, and SOX2 in cancer stem cells of HeLa. NC, negative control. (i) Western blot analysis of the stem cell markers NANOG, OCT4, CD133, and SOX2 in cisplatin-resistant HeLa cells after RNA interference targeting HOTAIR. (g) Statistic analysis relative destiny of (i). ^∗P values represent significant difference based on Student's t-test from three replicates (^∗P < 0.05, ^∗∗P < 0.01). miR-203 downregulated the expressions of stem markers of cervical cancer.