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. 2021 Sep 10;2021:4190764. doi: 10.1155/2021/4190764

Figure 5.

Figure 5

miR-203 downregulated the expressions of stem markers of cervical cancer. (a, b) Cancer stem cells of HeLa enriched by treatment with cisplatin (a) or culture in a serum-free medium (b) showed the downregulated expression of miR-203. (c–h) Expression changes of the stem markers NANOG, OCT4, CD44, ALDH1, CD133, and SOX2 in cancer stem cells of HeLa along with miR-203 alteration were detected and semiquantified by qRT-PCR. NC, negative control. (i). Western blot analysis of the stem cells markers NANOG, OCT4, CD133, and SOX2 in cisplatin-resistant HeLa cells along with miR-203 alteration. (g). Statistic analysis relative destiny of (i). ∗P values represent significant difference based on Student's t-test from three replicates (∗P < 0.05, ∗∗P < 0.01). HOTAIR interacted with miR-203 to post-transcriptionally regulate the expressions of ZEB1.