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. 2021 Aug 20;95(10):3205–3221. doi: 10.1007/s00204-021-03140-x

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — Concentration–response modelling of the cytotoxicity in Caco-2 cells of a abamectin (black upward triangle), Soprophor^® BSU (dark blue downward triangle), Soprophor^® 3D33 (green diamond), product 1 (red cross), combination of abamectin and respective co-formulants (light blue cross-square) and b fluroxypyr-meptyl (black upward triangle), Rhodacal^® 60/BE (green diamond), Solgad^® 150 ULN (dark blue downward triangle) and product 2 (red cross). The black lines are representing the dose–response curves of the mixtures under the assumption of dose addition of the single substances. Modelling was performed using the PROAST software ver. 70 (color figure online)