Table 6.
Characteristics of the 18 discrepant (Idylla MSS versus IHC dMMR) EC cases
| Case | Age (years) | Tumor cells (%) | Tissue area (mm2) | Macro-dissection | IHC (loss of MMR proteins) | Idylla MSI analysis | Number of mutated biomarkers | RER analysis (BAT25 and BAT26) |
|---|---|---|---|---|---|---|---|---|
| B14 | 69 | 30 | 300 | Yes | MSH2 | MSS | 0/7 | NDa |
| B66 | 79 | 50 | 40 | Yes | MLH1 | MSS | 0/7 | Negative |
| B79 | 72 | 50 | 30 | Yes | MSH6 | MSS | 0/7 | Negative |
| B80 | 73 | 40 | 50 | Yes | MLH1 | MSS | 0/7 | Negative |
| B97 | 53 | 60 | 75 | Yes | MLH1 | MSS | 0/7 | Negative |
| B107 | 77 | 70 | 100 | Yes | MLH1 | MSS | 0/7 | NDb |
| C1 | 59 | 40 | 50 | Yes | MSH6 | MSS | 0/7 | Negative |
| C4 | 72 | 60 | 50 | Yes | MSH6 | MSS | 0/7 | Negative |
| C7 | 58 | 50 | 300 | No | MSH6 | MSS | 0/7 | Positive |
| C9 | 66 | 70 | 15 | Yes | MSH6 | MSS | 0/7 | NDb |
| C13 | 63 | 80 | 75 | Yes | MSH6 | MSS | 0/7 | Negative |
| C17 | 78 | 80 | 75 | Yes | MSH6 | MSS | 0/7 | Positive |
| C19 | 69 | 40 | 100 | Yes | MLH1 | MSS | 0/7 | Negative |
| C20 | 61 | 80 | 150 | No | MSH6 | MSS | 0/7 | Negative |
| C21 | 49 | 80 | 75 | Yes | MSH6 | MSS | 0/7 | Positive |
| C22 | 72 | 80 | 100 | Yes | MLH1 | MSS | 1/7 | Negative |
| C26 | 80 | 30 | 25 | Yes | MSH6 | MSS | 0/7 | NDa |
| C29 | 58 | 60 | 100 | Yes | MSH6 | MSS | 0/7 | Positive |
dMMR deficient MMR protein expression, IHC immunohistochemistry, MMR mismatch repair, MSI microsatellite instable, MSS microsatellite stable, ND not determined, RER replication error
aTumor cell percentage less than 50%
bNot enough tissue available