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. 2021 Aug 25;95(10):3323–3340. doi: 10.1007/s00204-021-03128-7

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Reported and predicted blood concentrations of 3-OHBaP in rats upon (a) intravenous, (b) intratracheal and (c) oral exposure to 10 mg/kg BaP in rats. Symbols represent (a) the average blood concentrations reported in the in vivo studies of Moreau and Bouchard (2015) for intravenous (filled diamonds) and Marie et al. (2010) (open circles) for intravenous exposure. Symbols represent (b) the average blood concentrations reported in the in vivo studies of Moreau and Bouchard (2015) (grey open diamonds) and scaled Moreau and Bouchard data based on the fold difference observed in intravenous data (grey open triangles) upon intratracheal exposure. Symbols represent (c) the average blood concentrations reported in in vivo studies of Moreau and Bouchard (2015) (black open diamonds) and scaled Moreau and Bouchard data based on the fold difference observed in intravenous data (black open triangles) upon oral exposure. The lines represent the model predicted blood concentrations upon (a) intravenous (black solid line), (b) intratracheal (grey solid line) and (c) oral (black dashed line) exposure