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. 2021 Aug 25;95(10):3323–3340. doi: 10.1007/s00204-021-03128-7

Table 4.

Metabolites of BaP formed in incubations with rat liver microsomes and the corresponding kinetic parameters

Metabolites Structure Km, µM Vmax, pmol/min/mg microsomal protein Catalytic efficiency (Vmax/Km),
µl/min/mg protein
9,10-dihydro-B[a]P-diol graphic file with name 204_2021_3128_Figa_HTML.gif 11.9 ± 5.5 28.3 ± 2.8 2.4
4,5-dihydro-B[a]P-diol graphic file with name 204_2021_3128_Figb_HTML.gif 6.5 ± 4.5 13.3 ± 1.4 2.0
7,8-dihydro-B[a]P-diol graphic file with name 204_2021_3128_Figc_HTML.gif 14.6 ± 9.8 7.0 ± 1.1 0.5
7,8-dihydro-B[a]P-diol 12.6 ± 10.7 13.3 ± 2.5 1.1
B[a]P-1,6-quinone graphic file with name 204_2021_3128_Figd_HTML.gif 14.8 ± 8.8 22.2 ± 3.2 1.5
B[a]P-3,6-quinone graphic file with name 204_2021_3128_Fige_HTML.gif 24.0 ± 14.4 3.0 ± 0.5 0.1
9-hydroxy-B[a]P graphic file with name 204_2021_3128_Figf_HTML.gif 11.4 ± 5.2 20.0 ± 1.9 1.8
3-hydroxy-B[a]P graphic file with name 204_2021_3128_Figg_HTML.gif 34.2 ± 17.7 162.2 ± 47.6 7.8