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. 2021 Sep 17;12:5498. doi: 10.1038/s41467-021-25729-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Violin plot displaying the Log10 ratio between the viral titer at 48 h compared to 2 h post infection (p.i.) quantified by qPCR targeting the E gene in wildtype organoids and cells harboring a loss-of-function of a single host factor. Graphs display the ratio between viral titer at 48 h compared to 2 h post infection (p.i.). The dotted line indicates a fold change of 1. Dotted lines within the violins indicate the median and quartiles. N = 7 for WT, N = 3 for CEACAM1, DC-SIGN and MAVS, and N = 2 for the remaining genes. The WT data is redisplayed from Fig. 4a. b Model of host entry receptors and proteases involved in the entry of SARS-CoV-2. Essential and non-essential host factors based on the phenotypes in IO mutants are marked.