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. 2021 Sep 17;12:5506. doi: 10.1038/s41467-021-25777-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Binding (y-axis, ELISA assay) of SR6 variants identified by the second affinity maturation and two previously reported nanobodies, Nb21 and Ty1 (x-axis). Nanobody concentrations are shown at the bottom. Data shown are two technical replicates, bar height: mean, circle: the value of each replicate. b Biolayer interferometry assay of SR6v15. Red traces: recorded sensorgrams, black traces: fitted curves. K_D, K_a, and K_d values are the mean of five measurements. c Pseudovirus neutralization. % inhibition (y-axis) of different nanobodies (x-axis). Data shown are two technical replicates, bar height: mean, circle: the value of each replicate. d Dose–response curve for neutralization of pseudotyped lentiviral infection by nanobodies and nanobody-based agents. Markers: mean of three technical replicates, error bars: standard deviation. IC50 values are shown as mean ± standard deviation. Source data for a, c and d are provided in the Source Data file.