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. 2021 Sep 17;12:5514. doi: 10.1038/s41467-021-25799-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Quantification of co-localization of hTR with telomeres in G3 Pot1b^−/− sarcomas reconstituted with the indicated POT1b or tethered DNAs. 500 nuclei were analyzed per genotype. Data show the mean ± s.d. from three independent experiments. p-values are shown and generated from one-way ANOVA analysis followed by Tukey’s multiple comparison. b Quantification of telomere lengths by Q-FISH in G3 Pot1b^−/− sarcomas expressing POT1b or tethered DNAs. A minimum of 35 metaphases were analyzed per genotype. Box show the median and interquartile range (25% to 75%) from three independent experiments. p-values are shown and generated from one-way ANOVA analysis followed by Tukey’s multiple comparison. c Quantification of co-localization of hTR with telomeres in G3 Pot1b^−/− sarcomas reconstituted with the indicated POT1b or tethered DNAs. 500 nuclei were analyzed per genotype. Data show the mean ± s.d. from three independent experiments. p-values are shown and generated from one-way ANOVA analysis followed by Tukey’s multiple comparison. d Quantification of telomere lengths by Q-FISH in G3 Pot1b^−/− sarcomas expressing POT1b or tethered DNAs. At least 35 metaphases were analyzed per genotype. Boxes show the median and interquartile range (25% to 75%) from three independent experiments. p-values are shown and generated from one-way ANOVA analysis followed by Tukey’s multiple comparison. e Schematic of how POT1b promotes telomerase recruitment to telomeres. See text for details.