Table 6.

Responses of extensor digitorum longus (EDL) muscle proteins involved in metabolic processes to microgravity (µ-g) or artificial 1-g (A1-g) exposure and/or fructo-oligosaccharide (FOS) ingestion.

Gene symbol (accession)	µ-g & FOS (−)/A1-g & FOS (−)	µ-g & FOS (+)/A1-g & FOS (−)	A1-g & FOS (+)/A1-g & FOS (−)
Glycolytic process
Aldoa (P05064)	FC = 0.92, P = 6.1E−2	* FC = 0.88, P = 7.7E−3	FC = 1.02, P = 1.0E−1
Bpgm (P15327)	FC = 0.84, P = 6.6E−2	* FC = 0.84, P = 6.9E−4	FC = 1.05, P = 4.8E−1
Pfkm (P47857)	FC = 0.78, P = 2.4E−2	* FC = 0.55, P = 3.0E−3	FC = 0.92, P = 4.1E−1
Fatty acid beta-oxidation
Acox1 (Q9R0H0)	FC = 2.26, P = 2.7E−2	* FC = 3.70, P = 8.1E−3	FC = 1.71, P = 3.8E−2
Etfa (Q99LC5)	FC = 1.13, P = 1.1E−2	* FC = 1.17, P = 2.4E−3	FC = 1.00, P = 9.6E−1
Etfb (Q9DCW4)	FC = 1.15, P = 1.5E−2	* FC = 1.19, P = 3.5E−3	FC = 1.01, P = 6.4E−1
Tricarboxylic acid cycle
Aco1 (P28271)	* FC = 1.21, P = 5.9E−3	FC = 1.21, P = 8.0E−2	FC = 0.96, P = 3.7E−1
Idh2 (P54071)	* FC = 1.43, P = 8.5E−4	* FC = 1.45, P = 3.2E−4	FC = 0.98, P = 6.3E−1
Mdh1 (P14152)	FC = 1.05, P = 1.4E−1	* FC = 1.09, P = 6.2E−3	FC = 0.99, P = 8.0E−1
Ogdh (Q60597)	FC = 1.11, P = 3.1E−2	* FC = 1.09, P = 7.3E−4	FC = 1.01, P = 5.6E−1
Pdha1 (P35486)	* FC = 1.15, P = 5.2E−4	FC = 1.16, P = 1.8E−2	FC = 1.05, P = 3.6E−2
Suclg2 (Q9Z2I8)	FC = 1.36, P = 2.4E−2	* FC = 1.63, P = 5.1E−3	FC = 0.93, P = 5.5E−1

The protein abundance profiles of the groups exposed to µ-g with and without FOS ingestion and the group exposed to A1-g with FOS ingestion were individually compared with that of the group exposed to A1-g without FOS ingestion. The results for the proteins, which were categorized as the related factors to each metabolic process by DAVID Bioinformatics Resources 6.8 and significantly (p < 0.01) affected by µ-g exposure and/or FOS ingestion, in EDL muscles, are indicated. The fold change (FC) and p value (P) of each protein are depicted. *: the significant high- or low-abundance proteins.