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. 2021 Sep 17;4:1097. doi: 10.1038/s42003-021-02628-7

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Schematic of sutrode placement on the rat cVN, with a femoral arterial blood pressure sensor. a’ The cVN (black arrow) was interfaced with a sutrode (blue arrows). A conventional 4-0 nylon suture was used to isolate the carotid artery (yellow arrows). b Nitroprusside (red arrow) induced hypotension, that correlated with an increase in cVN firing rate (blue arrow). c Oxygen restriction induced an initial decrease (yellow arrowheads) and a subsequent 10-fold increase (blue arrowheads) in vagal activity. d Representative rate histogram of an isolated waveform (dark green bars), and graph (overlapped) of average total neuronal activity n = 6 experiments from n = 3 rats (averages ± SD), whiskers represent confidence intervals **p < 0.01. Oxygen restriction and restoration are pointed as red arrows in c. e The Oxygen reduction corresponded to a slight decrease in heart rate (blue arrow), and a subsequent increase in respiration rate calculated from f unfiltered raw data files. Values are from a representative rat, and overlapped bars are presented as the average ± SD of three rats.