Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2021 Sep 17;4:1097. doi: 10.1038/s42003-021-02628-7

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 5 — a NPS administration (orange arrow and dashed line) causes a reduction in cVN activity (Wf-a, yellow arrow), and activation of two separate Wf (Wf-a and b, green and blue arrows, respectively), as demonstrated by the frequency histograms (b), changes in amplitude of the signal at 200 s compared to baseline was 1.6 ± 1.02 µV (Supplementary Fig. 4). c Simultaneous recording of neural activity in the four splenic branches showed a differential temporal response in frequency firing, with SN-1 following the loss of cVN Wfa, and SN-2 and SN-4 activated simultaneously with VN Wf-c. Delta in amplitude in response to the drop in mean arterial pressure (baseline vs. 200 s after NPS administration) where 4.6 ± 1.3, 3.4 ± 1.9, 0.9 ± 0.8, 2.8 ± 1.2, for SN-1–4, respectively. Tukey’s multiple comparisons tests showed SN-1 vs. SN-3 **P = 0.006, alpha = 0.05, n = 5 (Supplementary Fig. 4). d Frequency histograms show specific time of increased activity over a 40% threshold (blue arrowheads in c and d). Representative waveforms were observed from n = 6 animals. NPS nitroprusside, cVN cervical vagus nerve, Wf waveform, SN splenic nerve.