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. 2021 Sep 17;11:18534. doi: 10.1038/s41598-021-97753-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Illustration of EV internalization by mDCs using confocal microscopy. (A) cells labeled with CD209 (red), a dendritic cell transmembrane antigen; (B) EVs stained with PKH67 (green); (C) nuclear staining with DAPI (blue); (D) Merge of CD209, DAPI and PKH67; (E–L) Sequential images using the z-stack tool of confocal microscopy depicting EVs inside the dendritic cells. Three-dimensional images of EVs and mDCs displayed in four angles of 45° displaying nuclei (blue), CD209 (red), EVs (green); (M) front view of the cells; (N) left lateral view of the cells; (O) right lateral view of the cells; (P) back view of the cells, indicating that the EVs were internalized by mono-DCs.