Table 3.
MiRNAs detected in EVs and respective gene targets associated with immune cell function found to be down-regulated in DCs treated with EVs.
| miRNAs# | Target gene of miRNAs in DCs* | Reported effects on DCs* | Cell type isolated# |
|---|---|---|---|
| miR-16-5p | FASN35 | Decreased differentiation36 | FaDu and SCC25 |
| miR-23b-5p | NOTCH and NF-kB37 | Decreased cytokine production38 | FaDu and SCC25 |
| miR-24-3p |
TNF-a, IL-6 and IL-1239 NF-kB40 |
Decreased antigen processing and presentation41 Decreased cytokine production39 |
FaDu and SCC25 |
| miR-181a-5p |
TNF-a, IL-1B, and IL-642 TNF-a43 |
Decreased cytokine production42 | FaDu and SCC25 |
| miR-17-5p | TNF-a and IL-1244 | Decreased maturation44 | SCC25 |
| miR-21-5p |
TNF-a45 CCL2046 |
Decreased migration and cytokine production47 | SCC25 |
| miR-152-3p | TMEM9748 | Decreased antigen processing and presentation49 | SCC25 |
| miR-155-5p | IL-150 |
Increased cell death51 Decreased maturation52 |
SCC25 |
| miR-212-3p | TGF-B53 | Decreased antigen processing and presentation29 | SCC25 |
Target genes reported here were studied in monocytes and/or dendritic cells according to references included in this table.
#Reported in this work.
*Reported in this work and literature.