Table 1.
Antiproliferative activity of prochelators and comparison compounds in cancer cell lines and normal lung fibroblasts.
| IC50 values (μM)[a] | ||||||
|---|---|---|---|---|---|---|
|
| ||||||
| MDA-MB-231 (Breast) | MCF-7 (Breast) | A2780 (Ovary) | Caco-2 (Colon) | HT-29 (Colon) | MRC-5 (Normal lung) | |
|
| ||||||
| (244mTC-S) 2 | 0.33 ± 0.06 | 0.12 ± 0.04 | 0.14 ± 0.04 | 0.38 ± 0.06 | 0.9 ± 0.2 | 17 ± 1 |
| (IT1-S) 2 | 0.35 ± 0.02 | 0.36 ± 0.02 | 0.21 ± 0.06 | 0.37 ± 0.02 | 0.85 ± 0.15 | 24 ± 2 |
| (TC1-S) 2 | 4.4 ± 0.7[b] | 12.3 ± 0.8[b] | n.d. | n.d. | n.d. | 30 ± 5[b] |
| (AH1-S) 2 | 6.7 ± 0.5[b] | 4.6 ± 0.9[b] | n.d. | n.d. | n.d. | 20 ± 1[b] |
| DFO | 5.8 ± 0.4 | 21 ± 2 | 3.83 ± 0.02 | 3.7 ± 0.3 | 2.4 ± 0.1 | 9 ± 1 |
[a]
IC50 values from MTT assays in the indicated cell lines after exposure to tested compounds for 72 h; values are presented as mean ± SDM, n = 3; n.d.: not determined.
[b]
As reported in Ref. 12.