Table 2:
Performance characteristics of the HR-B/V test in the training and validation cohorts.
| Test Group | AWA | AUC | PPA | NPA | Overall Accuracy | LR+ | LR− | F1 | PTP |
|---|---|---|---|---|---|---|---|---|---|
| Training Cohort | |||||||||
| Bacterial Infection | 83.3 (77.4-88.2) |
0.90 (0.84-0.94) |
85.3 (75.8-92.9) |
81.4 (75.0-86.8) |
82.6 (77.5-86.9) |
4.6 (3.2-6.8) |
0.18 (0.09-0.3) |
0.758 (0.676-0.829) |
52.2 (44.0-61.7) |
| Viral Infection | 85.9 (80.4-90.1) |
0.92 (0.87-0.95) |
85.9 (78.1-92.1) |
86.0 (78.9-90.9) |
85.9 (80.8-90.1) |
6.1 (4.1-10.0) |
0.16 (0.09-0.26) |
0.840 (0.772-0.892) |
91.6 (87.3-94.4) |
| Procalcitonin | 77.1 (70.4-83.0) |
0.84 (0.76-0.89) |
67.6 (54.3-77.6) |
86.2 (79.0-90.9) |
80.3 (74.6-85.4) |
4.9 (3.1-8.1) |
0.38 (0.25-0.52) |
0.687 (0.579-0.770) |
53.9 (43.1-67.4) |
| Validation Cohort | |||||||||
| Bacterial Infection | 80.1 (73.7-85.4) |
0.85 (0.78-0.90) |
79.1 (68.9-87.9) |
81.0 (73.6-86.9) |
80.4 (75.0-85.6) |
4.2 (2.9-5.9) |
0.26 (0.15-0.41) |
0.721 (0.626-0.794) |
49.9 (41.5-58.9) |
| Viral Infection | 86.8 (81.8-90.8) |
0.91 (0.85-0.94) |
89.0 (81.4-94.7) |
84.7 (77.1-90.5) |
86.6 (81.8-90.9) |
5.8 (3.8-9.4) |
0.13 (0.07-0.22) |
0.853 (0.796-0.901) |
91.2 (87.4-94.4) |
| Procalcitonin | 68.7 (62.4-75.4) |
0.72 (0.62-0.79) |
53.7 (41.0-65.3) |
83.1 (76.5-88.5) |
73.7 (66.7-79.4) |
3.2 (2.1-4.99) |
0.56 (0.43-0.71) |
0.567 (0.463-0.667) |
43.5 (33.7-54.6) |
All values are presented with a 95% confidence interval. AWA = Average Weighted Accuracy. PPA = Positive Percent Agreement. NPA = Negative Percent Agreement. LR+ = Likelihood Ratio Positive. LR- = Likelihood Ratio Negative. PTP = Bayesian post-test probability, representing the expected post-test probability for a pre-test probability with a uniform prevalence distribution in the range of 0.1-0.3 for bacterial infection and 0.5-0.8 for viral infection.