Table 1.
Baseline characteristics of study population.
| Variables | Overall N = 201 |
<70 N = 136 |
70+ N = 65 |
p-value* |
|---|---|---|---|---|
|
| ||||
| Sociodemographic | ||||
| Age, years, median (range) | 66.35 (range 26–83) | 62.5 (26–70) | 73.7 (70–83) | <0.001 |
| Gender, male, n (%) | 167 (83) | 108 (79) | 59 (91) | 0.045 |
| BMI, median (range) | 27 (16–51) | 27 (16–51) | 27 (19–38) | 0.159 |
| ECOG, median (range) | 0 (0–2) | 0 (0–2) | 1 (0–2) | 0.003 |
| Any Smoking Hx, n (%) | 151 (75) | 104 (76) | 47 (72) | 0.601 |
| ETOH use (severe), n (%)a | 35 (17) | 23 (17) | 12 (18) | 0.843 |
| Comorbidities | ||||
| Age-adjusted Charlson Comorbidity Index, median (range) | 5 (1–12) | 4 (1–11) | 6 (5–12) | <0.001 |
| CHF, n (%) | 7 (3) | 3 (2) | 4 (6) | 0.216 |
| CAD, n (%) | 33 (17) | 18 (13) | 15 (23) | 0.082 |
| HTN, n (%) | 107 (54) | 65 (48) | 42 (65) | 0.029 |
| COPD, n (%) | 17 (8) | 8 (6) | 9 (14) | 0.058 |
| DVT, n (%)b | 10 (5) | 5 (4) | 5 (8) | 0.300 |
| PVD, n (%) | 30 (15) | 22 (16) | 8 (12) | 0.472 |
| CVA, n (%) | 13 (6) | 7 (5) | 6 (9) | 0.271 |
| Cognitive impairment, n (%) | 1 (0.5) | 0 (0) | 1 (1.5) | 0.323 |
| Moderate/Severe CKD, n (%) | 5 (2) | 1 (0.7) | 4 (6) | 0.039 |
| Diabetes, n (%)c | 40 (20) | 22 (16) | 18 (28) | 0.056 |
| Prior CT surgery (any) | 25 (12) | 19 (14) | 6 (9) | 0.341 |
| Immunosuppression, n (%) | 15 (7) | 12 (9) | 3 (5) | 0.395 |
| Anticoagulated, n (%) | 25 (12) | 11 (8) | 14 (22) | 0.007 |
| Home 02, n (%) | 1 (0.5) | 1 (0.74) | 0 (0) | 1.000 |
| Pulmonary function testd N = 180 N = 121 N = 59 | ||||
| FEV1, mean ± SD | 87.5± 21.2 | 89.1 ±20.4 | 94.3± 22.6 | 0.197 |
| FVC %, mean ± SD | 92.8±17.5 | 94.5±17.2 | 89.3±17.7 | 0.086 |
| FEV1/FVC, mean, +/− SD | 0.94±0.13 | 0.94± 0.12 | 0.94± 0.15 | 0.969 |
BMI= Body-Mass Index; CAD= Coronary Artery Disease; CHF= Congestive heart failure; CKD = chronic kidney disease; COPD= Chronic obstructive pulmonary disease; CT = cardiothoracic; CVA= Cerebrovascular disease; DVT = Deep vein thrombosis; ECOG = Eastern Cooperative Oncology Group; EtOH = Ethanol; FEV1% = Forced expiratory volume in 1 s; FVC= Forced vital capacity; HTN = hypertension; 02 = oxygen; PVD= Peripheral Vascular disease; SD= Standard Deviation.
a
17 drinks/week or more.
b
Pre-treatment.
c
Insulin and non-insulin dependent diabetes.
d
PFTs means are reported out of total N that was available for each cohort due to missing data or in cases were PFTs were not performed.