Table 5.
Univariable and Multivariable Cox models for recurrence-free survival.
| Univariable | Multivariable | |||
|---|---|---|---|---|
|
| ||||
| variable | Hazard Ratio [95% CI] | p-value | Hazard Ratio [95% CI] | p-value |
| Age ≥ 70 years (ref. <70) | 0.832 [0.496, 1.396] | 0.4869 | 1.594 [0.812, 3.130] | 0.163 |
| Neoadjuvant, completion | Reference | Reference | – | |
| Neoadjuvant, dose reduced | 0.811 [0.325, 2.020] | 0.6525 | 0.697 [0.204, 2.379] | 0.5646 |
| Neoadjuvant, discontinued | 1.196 [0.546, 2.621] | 0.6542 | 2.784 [0.939, 8.258] | 0.0649 |
| Radiation dose, less than or equal 4500 g y | Reference | Reference | – | |
| Radiation dose >4500–5000 g y | 1.781 [0.378, 8.393] | 0.4653 | 0.895 [0.163, 4.918] | 0.8983 |
| Radiation dose >5000 g y | 1.296 [0.603, 2.783] | 0.5066 | 0.992 [0.436, 2.258] | 0.9843 |
| Surgery within 8 weeks of neoadjuvant (ref >8 weeks) | 0.753 [0.466, 1.218] | 0.2479 | 0.443 [0.230, 0.854] | 0.015 |
| Squamous cell Carcinoma (ref. Adenocarcinoma) | 0.534 [0.231, 1.235] | 0.1427 | 1.129 [0.382, 3.332] | 0.8263 |
| Pathological Stage T1/T2 (ref. pT0) | 2.649 [1.241, 5.658] | 0.0118 | 2.485 [0.772, 8.000] | 0.1269 |
| Pathological stage T3/T4 (ref. pT0) | 5.180 [2.486, 10.796] | <0.0001 | 4.947 [1.481, 16.531] | 0.0094 |
| Pathologic nodal disease N1–N3 (ref. pN0) | 3.075 [1.924, 4.915] | <0.0001 | 2.308 [1.130, 4.716] | 0.0217 |
| Lymphovascular invasion (ref. no) | 2.673 [1.574, 4.539] | 0.0003 | 2.229 [1.057, 4.699] | 0.0352 |
CI = confidence interval; Gy = Grey; N=Node descriptor; P = pathologic; T = tumor descriptor.