Table 2 :
Univariate and Multivariate Regression Analysis Associated with ERα Positivity
| HNSCC (n=318) | OPC (n=180) | |||||||
|---|---|---|---|---|---|---|---|---|
| Univariate OR (95% CI) | p | Multivariate OR (95% CI) | p | Univariate OR (95% CI) | p | Multivariate OR (95% CI) | p | |
| Tumor HPV Status | ||||||||
| Negative | Ref | Ref | Ref | Ref | ||||
| Positive | 27.5 (12.1–62) | <0.001 | 27.5 (11.4–66) | <0.001 | 23.0 (2.9–179) | 0.003 | 17.1 (2.1–137) | 0.007 |
| T Stage | ||||||||
| ≥T3 | Ref | Ref | Ref | Ref | ||||
| ≤T2 | 3.6 (1.9–7.1) | <0.001 | 2.2 (1.0–4.8) | 0.05 | 5.7 (2.1–14.9) | <0.001 | 4.0 (1.4–11.3) | 0.008 |
| Sex | ||||||||
| Female | Ref | Ref | ||||||
| Male | 2.0 (1.1–3.6) | 0.03 | 1.7 (0.74–3.8) | 0.21 | ||||
| Age | ||||||||
| ≤60 | Ref | Ref | ||||||
| >60 | 1.1 (0.7–1.7) | 0.73 | 1.4 (0.8–2.5) | 0.30 | ||||
| BMI | ||||||||
| <25 | Ref | Ref | ||||||
| ≥25 | 1.9 (1.1–3.3) | 0.015 | 1.9 (1.0–3.7) | 0.066 | ||||
| Pack-Years | ||||||||
| <10 | Ref | Ref | ||||||
| ≥10 | 1.4 (0.9–2.4) | 0.16 | 1.6 (0.8–3.0) | 0.19 | ||||
| Ever marijuana | ||||||||
| No | Ref | Ref | ||||||
| Yes | 1.6 (1.0–2.7) | 0.075 | 1.0 (0.5–2.1) | 0.12 | ||||
| Married/living with partner | ||||||||
| No | Ref | Ref | ||||||
| Yes | 1.7 (1.0–3.0) | 0.048 | 0.9 (0.4–1.8) | 0.68 | ||||
| # Any Sex Partners | ||||||||
| <20 | Ref | Ref | ||||||
| ≥20 | 2.3 (1.4–3.7) | 0.003 | 1.2 (0.6–2.2) | 0.58 | ||||
| # Oral Sex Partners | ||||||||
| <20 | Ref | 0.005 | Ref | |||||
| ≥20 | 2.0 (1.2–3.2) | 1.77 (0.9–3.3) | 0.064 | |||||
| Ever Oral Sex | ||||||||
| No | Ref | 0.004 | Ref | |||||
| Yes | 8.4 (2.0–36) | 4.1 (0.4–40) | 0.23 | |||||
| Daily Coffee Consumption | ||||||||
| <1 cup | Ref | 0.03 | Ref | |||||
| ≥ 1 cup | 1.8 (1.1–3.0) | 1.8 (0.9–3.4) | 0.08 | |||||
Abbreviations: HNSCC, head and neck squamous cell cancer; OPC, oropharynx cancer; OR, odds ratio; BMI, body mass index
Bolding indicates statistical significance.