Table 3:

Examining ERα IHC Staining Percentage and Intensity Categories In Relation to Overall Survival

		HNSCC (n=318)
ERα Staining Cutoffs	n	HR (95% CI)	aHR (95%CI)*
Percentage Positivity
<1%	203	Ref	Ref
≥1%	115	0.39 (0.18–0.85)	0.81 (0.26–2.51)
<10%	213	Ref	Ref
≥10%	105	0.47 (0.22–1.0)	1.1 (0.37–3.54)
<20%	241	Ref	Ref
≥20%	77	0.33 (0.12–0.93)	0.53 (0.11–2.50)
<35%	266	Ref	Ref
≥35%	52	0.40 (0.12–1.30)	0.59 (0.07–4.90)
Staining Intensity
0	203	Ref	Ref
1–3	115	0.39 (0.18–0.85)	0.81 (0.26–2.51)
0–1	226	Ref	Ref
2–3	92	0.40 (0.17–0.95)	0.77 (0.24–2.54)
0–2	271	Ref	Ref
3	47	0.55 (0.19–1.53)	1.07 (0.30–3.82)

^*Adjusted for age, HPV tumor status and smoking

Abbreviations: HNSCC, head and neck squamous cell cancer; HR, hazard ratio; CI, confidence interval; Ref, reference group.

Bolding indicates statistical significance.