Table.

Patient characteristics

Characteristic	Pt-1	Pt-2	Pt-3	Pt-4
Histology	Adenocarcinoma	Adenocarcinoma	Adenocarcinoma	Adenocarcinoma
EGFR Mutations	EGFR exon19del	EGFR exon19del	EGFR L858R+T790M	EGFR L858R+T790M
Sex	M	F	F	F
Age	76	42	80	57 (43 at diagnosis)
Smoking	20 pack-years	5 pack-years	Never	Never
Treatments	TKI failure (Osimertinib failure)	TKI failure (Afatinib failure)	TKI failure (Gefitinib failure)	TKI failure (Osimertinib failure)
Sample types	Liver biopsy	Pleural effusion	Bronsoscopy biopsy	Bronchoscopy biopsy
Raw reads	354,246,362	312,086,257	243,573,120	444,150,695
total cells after cut-off	3763	2651	747	936
included tumor cells	3697	118	237	166