Table 2.
The single nucleotide polymorphisms (SNPs) of the genes that attained a significant association with diabetic kidney disease in diabetic type 2 patients of Greek Caucasian origin. Polymorphisms are presented by level of significance based on increasing p value. The minor allele responsible for the SNP variant, the percentage of minor allele appearance in both case and control groups, and the major allele are shown. SNP: single nucleotide polymorphism; OR: odds ratio; CI: confidence interval; SE: standard error; NC: not calculable.
| Chromosome | SNP-gene | Minor allele | % of minor allele in case group patients | % of minor allele in control group patients | Major allele | χ 2 | p value | Odds ratio (OR) (CI: confidence interval) | Standard error (SE) |
|---|---|---|---|---|---|---|---|---|---|
| 4 | rs7685225-SPP1 | C | 25.21 | 37.27 | T | 10.28 | 0.001 | 0.567 (0.4-0.81) | 0.1779 |
| 2 | rs6588678-TPO | A | 51.24 | 38.86 | G | 9.743 | 0.002 | 1.653 (1.2-2.27) | 0.1616 |
| 2 | rs56307213-TTN | G | 4.959 | 1.136 | C | 9.385 | 0.002 | 4.539 (1.58-13.04) | 0.5385 |
| 2 | rs72648987-TTN | A | 4.959 | 1.142 | G | 9.318 | 0.002 | 4.518 (1.573-12.98) | 0.5385 |
| 2 | rs9678469-TPO | G | 17.36 | 9.545 | A | 8.818 | 0.002 | 1.99 (1.256-3.153) | 0.2348 |
| 2 | rs72650006-TTN | A | 6.25 | 2.074 | T | 7.849 | 0.005 | 3.148 (1.356-7.307) | 0.4296 |
| 2 | rs17532665-SGO2 | G | 18.6 | 10.91 | A | 7.832 | 0.005 | 1.865 (1.2-2.9) | 0.2251 |
| 7 | rs7830-NOS3 | A | 40.91 | 30.23 | C | 7.937 | 0.005 | 1.598 (1.152-2.217) | 0.1669 |
| 10 | rs45458497-PDLIM1 | C | 4.545 | 1.142 | T | 7.861 | 0.005 | 4.124 (1.416-12.01) | 0.5455 |
| 2 | rs17448235-SGO2 | G | 18.6 | 11.47 | A | 6.561 | 0.01 | 1.763 (1.138-2.732) | 0.2234 |
| 8 | rs11780592-CLU | G | 25 | 17.05 | A | 6.176 | 0.013 | 1.622 (1.105-2.381) | 0.1957 |
| 2 | rs1567919-TPO | T | 0 | 2.273 | G | 5.582 | 0.018 | 0 | Infinite |
| 2 | rs13431646-TPO | T | 0 | 2.273 | C | 5.582 | 0.018 | 0 | Infinite |
| 2 | rs72677233-TTN | T | 1.24 | 0 | C | 5.479 | 0.019 | NC | NC |
| 2 | rs72646855-TTN | C | 1.24 | 0 | T | 5.454 | 0.019 | NC | NC |
| 11 | rs486584-CCS | G | 43.39 | 52.73 | A | 5.447 | 0.019 | 0.6871 (0.5011-0.9422) | 0.1611 |
| 19 | rs201633492-GPX4 | A | 1.24 | 0 | G | 5.479 | 0.019 | NC | NC |
| 22 | rs201971987-TXNRD2 | G | 1.24 | 0 | A | 5.479 | 0.019 | NC | NC |
| 22 | rs737866-TXNRD2 | G | 38.02 | 29.32 | A | 5.393 | 0.02 | 1.479 (1.062-2.059) | 0.1688 |
| 4 | rs2725236-SPP1 | T | 38.02 | 46.82 | C | 4.916 | 0.026 | 0.6967 (0.5059-0.9595) | 0.1633 |
| 2 | rs6732480-TPO | T | 51.24 | 42.5 | C | 4.807 | 0.028 | 1.422 (1.038-1.948) | 0.1607 |
| 8 | rs2741335-EPHX2 | G | 38.84 | 30.68 | T | 4.663 | 0.031 | 1.435 (1.033-1.993) | 0.1676 |
| 11 | rs3019593-MTL5 | G | 11.57 | 6.818 | A | 4.531 | 0.033 | 1.788 (1.041-3.071) | 0.276 |
| 2 | rs2048727-TPO | A | 42.5 | 34.32 | G | 4.45 | 0.035 | 1.415 (1.024-1.954) | 0.1647 |
| 17 | rs9904720-EPX | A | 37.19 | 29.32 | C | 4.438 | 0.035 | 1.427 (1.024-1.989) | 0.1693 |
| 5 | rs2230303-GPX3 | G | 1.653 | 0.2273 | T | 4.36 | 0.036 | 7.378 (0.82-66.39) | 1.121 |
| 4 | rs6833161-SPP1 | T | 33.88 | 42.01 | C | 4.321 | 0.037 | 0.7075 (0.5102-0.981) | 0.1668 |
| 5 | rs8177413-GPX3 | C | 1.653 | 0.2294 | G | 4.308 | 0.037 | 7.311 (0.8125-65.78) | 1.121 |
| 8 | rs7824574-CLU | A | 5.785 | 10.45 | C | 4.243 | 0.039 | 0.5259 (0.2829-0.9778) | 0.3164 |
| 22 | rs12106549-TXNRD2 | T | 25.62 | 18.86 | G | 4.257 | 0.039 | 1.482 (1.019-2.155) | 0.1911 |
| 17 | rs14309-ALOX12 | A | 7.438 | 12.5 | G | 4.186 | 0.04 | 0.5625 (0.3222-0.9819) | 0.2843 |
| 6 | rs1293928-IPCEF1 | G | 30.58 | 38.41 | A | 4.174 | 0.041 | 0.7063 (0.5057-0.9866) | 0.1705 |
| 6 | rs6905523-GSTA7P | G | 26.03 | 19.32 | A | 4.143 | 0.041 | 1.47 (1.013-2.133) | 0.1898 |
| 8 | rs10087808-OXR1 | G | 22.31 | 29.55 | A | 4.144 | 0.042 | 0.6849 (0.4753-0.9871) | 0.1864 |
| 6 | rs35062161-GPX6 | T | 3.719 | 1.364 | A | 4.027 | 0.044 | 2.794 (0.9824-7.946) | 0.5333 |
| 8 | rs10109171-OXR1 | A | 38.43 | 30.82 | G | 4.048 | 0.044 | 1.401 (1.008-1.947) | 0.1678 |
| 2 | rs2465661-AOX1 | T | 38.02 | 45.91 | C | 3.966 | 0.046 | 0.7226 (0.5246-0.9954) | 0.1634 |
| 7 | rs6947821-NOS3 | C | 29.75 | 37.27 | T | 3.902 | 0.048 | 0.7128 (0.5091-0.998) | 0.1717 |
| 8 | rs10108813-OXR1 | C | 22.73 | 29.77 | T | 3.907 | 0.048 | 0.6938 (0.4823-0.9979) | 0.1855 |
| 6 | rs72944451-GSTA4 | T | 2.479 | 68.18 | G | 3.874 | 0.049 | 3.703 (0.9179-14.94) | 0.7117 |
| 8 | rs1503573-OXR1 | G | 42.15 | 50 | A | 3.862 | 0.049 | 0.7286 (0.531-0.9996) | 0.1614 |
| 17 | rs11652709-EPX | C | 37.6 | 30.23 | G | 3.851 | 0.049 | 1.391 (1-1.935) | 0.1685 |
| 20 | rs6052780-PRNP | A | 1.65 | 4.545 | G | 3.848 | 0.049 | 0.3529 (0.1192-1.045) | 0.5537 |