Table 3.
Effect Estimates and P Values for the Multivariate Model Predicting Coronary Artery Calcium Scores in the SCCOR Cohort (n = 413; Those With Clinical CAD Were Excluded)
| Variable | Multivariate OR (95% CI) | P Value |
|---|---|---|
| Pulmonary phenotypes | ||
| RV to TLC ratio, per 0.20 increase | 3.2 (1.6-6.4) | .001 |
| FEV1, per 20 % predicted decrease | 1.0 (0.6-1.5) | .92 |
| FEV1 to FVC ratio, per 0.20 decrease | 1.0 (0.3-1.2) | .12 |
| Visual emphysema score, per 1-unit increase | 1.1 (0.9-1.4) | .31 |
| Mean lumen perimeter, per 1-mm increase | 1.1 (0.9-1.3) | .17 |
| Dlco, per 20% predicted decrease | 1.2 (0.9-1.5) | .28 |
| Demographics | ||
| Age, per 10-y increase | 1.8 (1.3-2.6) | .001 |
| Male sex | 3.5 (2.3-5.4) | < .001 |
| Non-Hispanic White | 2.3 (0.9-5.8) | .07 |
| Cardiovascular risk factors | ||
| Hypertension | 1.4 (0.9-2.0) | .09 |
| Diabetes mellitus | 1.6 (0.8-3.2) | .16 |
| Hyperlipidemia | 1.6 (1.1-2.3) | .01 |
| Pack-years of smoking, per 10-y increase | 1.1 (1.0-1.2) | .04 |
| Current smoking | 1.0 (0.7-1.4) | .90 |
CAD = coronary artery disease; Dlco = diffusing capacity for carbon monoxide; RV = residual volume; SCCOR = University of Pittsburgh COPD Specialized Center for Clinically Oriented Research; TLC = total lung capacity.