Table 5.
Hematologic Malignancies Model Univariate and Multivariate Analysis
| Parameter | Univariate Analysis Cox Model |
Multivariate Analysis Cox Model |
||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P Value | HR | 95% CI | P Value | |
| Age | 1.01 | 1.00-1.02 | .115a | ... | ... | ... |
| Male sex | 1.04 | 0.73-1.47 | .843 | ... | ... | ... |
| ECOG score | ... | ... | < .001a | ... | ... | .003 |
| 0-1 | 1 | ... | ... | ... | ... | ... |
| 2-4 | 2.71 | 1.58-4.67 | ... | 2.31 | 1.33-4.03 | ... |
| CHF present | 1.47 | 0.92-2.35 | .107a | ... | ... | ... |
| Ascites present | 1.78 | 1.12-2.81 | .014a | ... | ... | ... |
| High clinical suspicion of pneumonia | 1.77 | 1.23-2.56 | .002a | 1.65 | 1.10-2.48 | .02 |
| Chemotherapy within 30 d prior | 1.46 | 1.00-2.14 | .053a | ... | ... | ... |
| Radiation within 30 d before tap | 2.11 | 1.07-4.15 | .032a | ... | ... | ... |
| Surgery within 30 d before tap | 7.00 | 0.96-51.25 | .055a | ... | ... | ... |
| Right-sided effusion present | 1.10 | 0.78-1.55 | .601 | ... | ... | ... |
| Bilateral effusion present | 0.78 | 0.54-1.11 | .166a | 0.59 | 0.39-0.88 | .01 |
| Size of the effusion on chest radiograph | ||||||
| Up to apex diaphragm | 1 | ... | ... | ... | ... | ... |
| Up to vascular pedicle | 1.14 | 0.66-1.95 | .64 | ... | ... | ... |
| Up to top of cardiac silhouette | 0.91 | 0.50-1.65 | .76 | ... | ... | ... |
| Up to top of aortic arch | 1.49 | 0.64-3.45 | .35 | ... | ... | ... |
| Higher than aortic arch | 2.05 | 0.85-4.95 | .11a | ... | ... | ... |
| Lung or pleural nodularity thickening or mass of 1 cm during study within 30 d before first tap | 1.08 | 0.75-1.56 | .687 | ... | ... | ... |
| Malignant pleural fluid cytologic findings | 1.56 | 1.09-2.23 | .015a | 2.07 | 1.40-3.05 | < .001 |
| Neutrophil to lymphocyte ratio | 1.00 | 1.00-1.01 | .524 | ... | ... | ... |
| Amount of fluid drained | 1.00 | 1.00-1.00 | .981 | ... | ... | ... |
| Pleural fluid LDH/100 | 1.00 | 1.00-1.01 | .709 | ... | ... | ... |
| Pleural fluid protein | 0.69 | 0.56-0.85 | < .001a | 0.67 | 0.52-0.85 | .001 |
| Pleural fluid cholesterol | 0.98 | 0.97-0.99 | .002a | ... | ... | ... |
| Pleural fluid triglycerides | 1.00 | 1.00-1.00 | .076a | ... | ... | ... |
CHF = congestive heart failure; ECOG = Eastern Cooperative Oncology Group; HR = hazard ratio; LDH/100 = pleural fluid lactate dehydrogenase/100.
a
Because of variable distribution within this cohort, ECOG score was split into only two categories.