Table 4.
Box-Behnken design responses observed for Farnesol loaded niosomes (Mean ± S.D) (n = 3).
| Independent variables |
Dependent variables |
||||
|---|---|---|---|---|---|
| Run | A: Cholesterol: Span 20 (ratio) | B: Farnesol (mg) | C: Homogenization speed (rpm) | Particle size (nm) | % Entrapment efficiency (Farnesol) |
| 1 | 0 | 0 | 0 | 230.12 ± 2.21 | 69.62 ± 0.10 |
| 2 | 0 | 1 | -1 | 310.13 ± 1.12 | 58.83 ± 0.44 |
| 3 | 1 | 0 | -1 | 342.42 ± 4.91 | 49.74 ± 1.12 |
| 4 | 0 | -1 | 1 | 289.32 ± 0.54 | 70.32 ± 0.42 |
| 5 | -1 | -1 | 0 | 154.12 ± 0.54 | 79.93 ± 0.41 |
| 6 | 0 | 0 | 0 | 231.13 ± 4.71 | 69.61 ± 3.22 |
| 7 | -1 | 1 | 0 | 168.36 ± 2.32 | 83.53 ± 0.22 |
| 8 | 0 | 0 | 0 | 230.34 ± 1.21 | 69.94 ± 0.34 |
| 9 | 1 | -1 | 0 | 325.43 ± 3.22 | 61.22 ± 0.41 |
| 10 | -1 | 0 | 1 | 210.14 ± 2.12 | 67.41 ± 1.91 |
| 11 | 1 | 0 | 1 | 388.31 ± 5.24 | 45.23 ± 0.15 |
| 12 | 1 | 1 | 0 | 356.26 ± 3.73 | 56.42 ± 0.31 |
| 13 | -1 | 0 | -1 | 250.33 ± 1.72 | 65.44 ± 0.22 |
| 14 | 0 | 1 | 1 | 386.09 ± 6.24 | 52.73 ± 1.41 |
| 15 | 0 | -1 | -1 | 264.31 ± 1.11 | 65.24 ± 0.14 |