Table 5.
A) Responses of regression analysis for Y1 (Particle size), Y2 (%EE FAR); B) Optimized niosomal formula.
| A) | ||||||||
|---|---|---|---|---|---|---|---|---|
| Response | Model | Adequate precision | R2 | Adjusted R2 | Predicted R2 | SD | % CV | p-value |
| Y1 (Particle size) | Linear, Quadratic | 43.96 | 0.99 | 0.99 | 0.83 | 7.27 | 2.59 | <0.0001 |
|
Y2 (%EE FAR) |
Quadratic |
31.1 |
0.99 |
0.98 |
0.92 |
0.79 |
2.22 |
0.0004 |
| B) | ||||||||
| Factor | Optimized level | |||||||
| X1: Cholesterol: Span20 (ratio) | 1:1 | |||||||
| X2: Drug (mg) | 0.5 | |||||||
| X3: Stirring speed (rpm) | 8500 | |||||||
| Response | Expected | Observed | Residual | |||||
| Y1 (particle size nm) | 168 | 168.87 | -0.87 | |||||
| Y2 (%EE Farnesol) | 83.5 | 85.67 | 2.17 | |||||